[Answer]

You live in the dmv area, right? At the end of the day, funny is funny and people will generally react regardless. I moved from doing stuff in Maryland/DC/VA to Mobile, Alabama and really wasn’t sure how different the scene would be, but it’s pretty much the same with regards to content (the only real difference is there’s not NEARLY as many open mics down here)

As far as college kids/millennials I really doubt they’re your issue. Especially if it’s in the Midwest, I imagine they’re the more conservative type and 99% of my experience of seeing someone get offended by any material has been middle aged and older people who probably had no business being at a comedy show to begin with. But you should have enough material to adapt to the crowd. If you’re doing something on the west coast, you’d probably have a more sensitive crowd