are you planning on doing anything cpu intensive? graphics, gaming, datamining?
if so you would need something towards the high end of the range of these devices (Yoga Pro, Surface, etc) to do what you need
Otherwise for normal computer tasks the 2-in-1s are fine. they tend to be speced lighter than their laptop counterparts for portability. just make sure whatever you get has an actual PC CPU (should be Ivy Bridge atm), not one of the smaller ones they use in phones or netbooks (Atom).
You'll also want something with 4gb or more of ram if you can find it, or possibly expandable memory so you can add more. ram is pretty cheap, but afaik most of the 2 in ones dont have user accessible memory so you might be stuck with whatever it comes with out of the box.
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