every scientific breakthrough was intuitively led. We lead with a certain hunch that we have and then follow up with experimentation. Every advancement in science was due to an imaginative mind, saying, what if. In this way, of course some things which people intuitively assume will be wrong. I mean even today, we have quantum mechanics, the properties of which defies things we thought we knew about physics.
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I'm not assuming we know everything about either the brain or the universe, but I DO know that the brain primarily interprets sensory data gathered through our sensory organs whereas the Universe is an inanimate macroscopic entity that I doubt is sentient, and exists for the sole purpose of containment
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You don't need to know everything about a person to know that they are good at a certain skill, true
Just as you don't need to know everything about the brain to know that it thinks
But
Our knowledge of the nature and function of thought in a cosmological sense cannot be known with the information that science currently provides. Some people seem to think we may never know.
We hold science to be the pinnacle of human thought process. Our greatest achievement as a species. In accepting this notion however, we have the tendency to denounce other modes of thought. Even cultural modes of thought that somehow bred thriving societies.